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This model will contain a bi-allelic deletion within the Mrp2 gene, synonym Abcc2 (ATP-binding cassette, sub-family C [CFTR/MRP], member 2), encoding a multispecific organic anion transporter.
This model will contain a bi-allelic deletion within the Park2 gene, Parkinson disease (autosomal recessive, juvenile) 2, encoding for the protein Parkin that localizes to the cytoplasm of neurons and mediates the degradation of improperly folded proteins.
This model will contain a bi-allelic deletion within the Park7 (Parkinson disease [autosomal recessive, early onset] 7) gene, synonym DJ-1, encoding for the protein Park7 that belongs to the peptidase C56 family of proteins.
This model will contain a bi-allelic deletion within the Pink1 (PTEN-induced putative kinase 1) gene, encoding for a serine/threonine protein kinase. Mutations in Pink1 are implicated in early-onset Parkinson's disease.
This model will contain a bi-allelic deletion within the Prkdc (protein kinase, DNA-activated, catalytic polypeptide) gene, which is a component of the autoimmune antigen Ku.
This model will contain a bi-allelic deletion within the Nr1i2 (nuclear receptor, sub-family 1, group I, member 2) gene, encoding for the Pregnane X receptor (PXR).
This model will contain a bi-allelic deletion within the Rag1 (Recombination activating 1) gene, encoding for the Recombination activating protein 1, which is essential for the development of mature B and T lymphocytes.
This model will contain a bi-allelic deletion within the Rag2 (Recombination activating 2) gene, encoding for the Recombination activating protein 2, which is essential for the development of mature B and T lymphocytes.
This model will contain a bi-allelic deletion within the Snca gene, encoding for synuclein, alpha (non-A4 component of amyloid precursor) protein, which plays a role in synaptic biogenesis and organization.
This model contains a bi-allelic 14 base pair deletion within exon 3 of the most commonly mutated gene in human cancers, Tp53 (Tumor protein p53). This deletion causes a frameshift in the coding region, resulting in a premature termination codon at the end of exon 3.
