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This model will contain a bi-allelic deletion within the ApoE gene, encoding a glycoprotein, Apolipoprotein E.

This model will contain a bi-allelic deletion within the Bcrp gene, synonym Abcg2 (ATP-binding cassette, subfamily G, member 2), encoding for an ATP drug transporter.

This model will contain a deletion on one allele within the Bdnf (Brain-derived neurotrophic factor) gene, encoding for the nerve growth factor protein Bdnf. Homozygous animals carrying the Bdnf deletion are postnatal lethal.

This model will contain a bi-allelic deletion within the Disc1 (Disrupted in Schizophrenia 1) gene, encoding the Disc1 protein.

This model will contain a bi-allelic deletion within the Foxn1 gene, encoding for the Forkhead box protein n1, which is a transcription factor involved in generation of T lymphocytes.

This model will contain a bi-allelic deletion within the Ldlr (low-density lipoprotein receptor) gene, encoding for the protein Ldlr.

This model will contain a bi-allelic deletion within the obesity gene, Lep, encoding for the protein leptin. Leptin plays a key role in regulating appetite and metabolism.

This model will contain a bi-allelic deletion within the Lrrk2 gene, encoding for the leucine-rich repeat kinase 2.

This model contains a bi-allelic deletion of 20 base pairs within exon 7 of the multi-drug resistance gene Mdr1a, synonym Abcb1a (ATP-binding cassette, sub-family B [MDR/TAP], member 1A), encoding P-glycoprotein 3. The deletion causes a frameshift in the coding region, resulting in a premature termination codon at the end of exon 7.

This model will contain a bi-allelic deletion within the Mrp1 gene, synonym Abcc1a (ATP-binding cassette, sub-family C [CFTR/MRP], member 1a), encoding an ATP-dependent drug transporter.