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This model will contain a bi-allelic deletion within the ApoE gene, encoding a glycoprotein, Apolipoprotein E.

This model will contain a deletion on one allele within the Bdnf (Brain-derived neurotrophic factor) gene, encoding for the nerve growth factor protein Bdnf. Homozygous animals carrying the Bdnf deletion are postnatal lethal.

This model will contain a bi-allelic deletion within the Disc1 (Disrupted in Schizophrenia 1) gene, encoding the Disc1 protein.

This model will contain a bi-allelic deletion within the Lrrk2 gene, encoding for the leucine-rich repeat kinase 2.

This model will contain a bi-allelic deletion within the Park2 gene, Parkinson disease (autosomal recessive, juvenile) 2, encoding for the protein Parkin that localizes to the cytoplasm of neurons and mediates the degradation of improperly folded proteins.

This model will contain a bi-allelic deletion within the Park7 (Parkinson disease [autosomal recessive, early onset] 7) gene, synonym DJ-1, encoding for the protein Park7 that belongs to the peptidase C56 family of proteins.

This model will contain a bi-allelic deletion within the Pink1 (PTEN-induced putative kinase 1) gene, encoding for a serine/threonine protein kinase. Mutations in Pink1 are implicated in early-onset Parkinson's disease.

This model will contain a bi-allelic deletion within the Snca gene, encoding for synuclein, alpha (non-A4 component of amyloid precursor) protein, which plays a role in synaptic biogenesis and organization.