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This model will contain a bi-allelic deletion within the Foxn1 gene, encoding for the Forkhead box protein n1, which is a transcription factor involved in generation of T lymphocytes.

This model contains a bi-allelic 14 base pair deletion within exon 3 of the most commonly mutated gene in human cancers, Tp53 (Tumor protein p53). This deletion causes a frameshift in the coding region, resulting in a premature termination codon at the end of exon 3.

This model will contain a bi-allelic deletion within the Prkdc (protein kinase, DNA-activated, catalytic polypeptide) gene, which is a component of the autoimmune antigen Ku.

This model will contain a bi-allelic deletion within the Rag1 (Recombination activating 1) gene, encoding for the Recombination activating protein 1, which is essential for the development of mature B and T lymphocytes.

This model will contain a bi-allelic deletion within the Rag2 (Recombination activating 2) gene, encoding for the Recombination activating protein 2, which is essential for the development of mature B and T lymphocytes.