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Leading-edge technology – SAGE™ Labs presents next-generation animal research models, featuring CompoZr™ ZFN technology.
p53 Knockout Rat - Speed up your carcinogenicity assay with a more predictive model.
Mdr1a Knockout Rat - Effectively screen for P-gp drug interactions.
SAGE Labs Models in Development ::
  • Oprk1 (KOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Ank3 Bi-Polar disorder Neuroscience

    Ank3 was identified through genome association studies to be a candidate for Bi-Polar Disorder.

  • Scn9A pain/sensorial - Neuroscience

    Sodium Channel 1.7 deficient rats could be useful for sensorial perception research.

  • CACNA1C Bi-Polar disorder - Neuroscience

    CACNA1C was identified through genome association studies to be a candidate for Bi-Polar Disorder.

  • Oprd1 (DOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Brd1 Bi-Polar disorder - Neuroscience

    Brd1 was identified through genome association studies to be a candidate for Bi-Polar Disorder.

  • Oprm1 (MOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

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Search Results >Cardiology Research Models
  • ApoE Knockout Rat

    This model will contain a bi-allelic deletion within the ApoE gene, encoding a glycoprotein, Apolipoprotein E.

    More Information on ApoE Knockout Rat
  • Ldlr Knockout Rat

    This model will contain a bi-allelic deletion within the Ldlr (low-density lipoprotein receptor) gene, encoding for the protein Ldlr.

    More Information on Ldlr Knockout Rat
  • Leptin Knockout Rat

    This model will contain a bi-allelic deletion within the obesity gene, Lep, encoding for the protein leptin. Leptin plays a key role in regulating appetite and metabolism.

    More Information on Leptin Knockout Rat
SAGE Labs News ::
  • Sigma® Life Science extends research model portfolio into Oncology and Carcinogenicity screening
    Apr 19 2010
  • Sigma-Aldrich Further Expands In Vivo Biology Offering with Acquisition of Ace Animals, Inc.
    Mar 16 2010
  • Sigma Life Science Introduces World's First Suite of Knockout Rats for ADME/Tox Applications
    Mar 8 2010
  • Generation of Knockout Rats with X-Linked Severe Combined Immunodeficiency (X-SCID) using Zinc-Finger Nucleases
    Jan 25 2010
  • Sigma-Aldrich's Targeted Knockout Rat Ranks in Top 5 of The Scientist Magazine's Top 10 Innovations for 2009
    Dec 3 2009
SAGE Labs Community ::
  • Disc1
    Jan 29 2010
  • Lep/Alz
    Jul 5 2010
  • A cre rat and HR in rats?
    Jun 18 2010
  • Tox models
    Jan 29 2010
  • Park2 knockout
    Jan 29 2010
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