Search by Application and/or Keyword

This model will contain a bi-allelic deletion within the Bcrp gene, synonym Abcg2 (ATP-binding cassette, subfamily G, member 2), encoding for an ATP drug transporter.

This model contains a bi-allelic deletion of 20 base pairs within exon 7 of the multi-drug resistance gene Mdr1a, synonym Abcb1a (ATP-binding cassette, sub-family B [MDR/TAP], member 1A), encoding P-glycoprotein 3. The deletion causes a frameshift in the coding region, resulting in a premature termination codon at the end of exon 7.

This model will contain a bi-allelic deletion within the Mrp1 gene, synonym Abcc1a (ATP-binding cassette, sub-family C [CFTR/MRP], member 1a), encoding an ATP-dependent drug transporter.

This model will contain a bi-allelic deletion within the Mrp2 gene, synonym Abcc2 (ATP-binding cassette, sub-family C [CFTR/MRP], member 2), encoding a multispecific organic anion transporter.

This model will contain a bi-allelic deletion within the Nr1i2 (nuclear receptor, sub-family 1, group I, member 2) gene, encoding for the Pregnane X receptor (PXR).