|
username:
password:
SAGE™ Space
twitter

Please wait while our tweets load

If you can't wait - check us out at twitter

tweet foot
SAGE Labs Models in Development ::
  • CACNA1C Bi-Polar disorder - Neuroscience

    CACNA1C was identified through genome association studies to be a candidate for Bi-Polar Disorder.

  • Oprd1 (DOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Oprk1 (KOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Oprm1 (MOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Scn9A pain/sensorial - Neuroscience

    Sodium Channel 1.7 deficient rats could be useful for sensorial perception research.

  • Brd1 Bi-Polar disorder - Neuroscience

    Brd1 was identified through genome association studies to be a candidate for Bi-Polar Disorder.

  • Ank3 Bi-Polar disorder Neuroscience

    Ank3 was identified through genome association studies to be a candidate for Bi-Polar Disorder.

Visit other Sigma Bio sites

sideFadeLine
Animal Research Models Banner
Park2 Knockout Rat
Model Detail >
Blue Fade Line
Park2 Knockout Rat
Nomenclature: SD- Park2 tm1sage
Genotype: Homozygous
Product number: In Development
List pricing: TBD

Request a quote and a SAGE™ Labs research specialist will contact you with an estimated price and delivery date.

Pre-Order
Description - This model will contain a bi-allelic deletion within the Park2 gene, Parkinson disease (autosomal recessive, juvenile) 2, encoding for the protein Parkin that localizes to the cytoplasm of neurons and mediates the degradation of improperly folded proteins.
Additional Information
In humans, loss of function of Park2 leads to a form of familial Parkinson's disease. The Parkin protein is part of the ubiquitin-proteasomal enzyme pathway and may help degrade other proteins that are toxic to neurons. Roughly 20% of patients with Parkinson's disease onset before age 40 have mutations within Park2, making this an ideal model for the study of Parkinson's disease.
Research Applications

Parkinson's disease
Dopaminergic cell toxicity

 
Share
SAGE Labs Community ::