Rag2 knockout rats completely lack B and T cells, making them ideal immuno-compromised hosts for xenograft studies. In addition, the larger size of the rat makes performing sophisticated xenograft techniques and surgeries much simpler as compared to similar studies in a mouse.
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Figure 1. Flow cytometric analysis of T cell subsets (CD4 and CD8), B cells and NK cells from wild type and Rag2 (-/-) knockout blood samples
The top panels represent wild type female and male rats. The lower panels represent samples from female and male Rag2 (-/-) knockout rats. Blood samples were collected from 4- and 10-week-old rats.
Normal rat chow
Mature B and T cells are critical components for an adaptive immune system. Rats deficient in Rag2 protein produce no mature B or T cells. This non-leaky model for severe combined immune deficiency is useful for vaccine development, autoimmune and infectious diseases.
