Boost your PK/PD studies to new levels with the ADME Knockout Rat collection from SAGE™ Labs. Learn More
Expand your research — New inbred
and outbred mouse and rat strains from
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This model will contain a bi-allelic deletion within the Rag2 (Recombination activating 2) gene, encoding for the Recombination activating protein 2, which is essential for the development of mature B and T lymphocytes.
Mature B and T cells are critical components for an adaptive immune system. Rats deficient in Rag2 protein produce no mature B or T cells. This non-leaky model for severe combined immune deficiency is useful for vaccine development, autoimmune and infectious diseases.
- AIDS and other autoimmune disorders
- Vaccine development
- Transplantation studies
- Hematopoieses
- Immune cell differentiation
