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Rag1 Knockout Rat
Model Detail >
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Downloads

application/pdf iconRAG1_Data_Sheet.pdf
File size: 581.22k
application/pdf iconRag 1 Harlan Health Report 1.4.12.pdf
File size: 18.73k
Rag1 Knockout Rat
Nomenclature: SD- Rag1 tm1sage
Genotype: Homozygous
Product number: TGRS3920
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Description

This model contains a full ablation of the Recombination activating protein 1 (Rag1), which is essential for the development of mature B and T lymphocytes. Protein ablation has been demonstrated by Western Blot.
Additional Information

Mature B and T cells are critical components for an adaptive immune system. Rats deficient in Rag1 protein produce no mature B or T cells. This non-leaky model for severe combined immune deficiency is useful for vaccine development, as well as the study of autoimmune and infectious diseases.

Characteristics
  • Sprague-Dawley background strain
  • Homozygous knockouts display total loss
    of Rag1 protein via Western blot
  • Homozygous Rag1 knockout rats show loss
    of B and T cells by FACS analysis
  • Expect a phenotypic 5-8% loss of animals around 8 weeks of age due to Severe Chronic Interstitial Myocarditis. Please consider the loss of animal when placing orders.

    • See Product Data Sheet for Details.

    Research Applications
    • AIDS and other autoimmune disorders
    • Oncology and Xenograft Studies
    • Vaccine development
    • Transplantation studies
    • Hematopoieses
    • Immune cell differentiation
    Diet

    Normal rat chow

     
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