PXR Knockout Rat
Model Detail >
Nomenclature:
SD-
Nr1i2
tm1sage
Genotype:
Homozygous
Product number:
TGRS4130
Research Applications
- Xenobiotic sensor
- Cytochrome p450 pathways
- Drug metabolism
- Hepatotoxicity
- Cholestasis
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Description
PXR is involved in the induction of cytochrome p4503A (Cyp3a) and is abundantly expressed in the liver and intestine. This model is useful for studying metabolism of xenobiotic compounds and hepatotoxicity.
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Characteristics
- Biallelic 20 bp deletion within Nr1i2 gene
- Lacks induction of Cyp3a1
- Background Strain: Sprague-Dawley
Figure 1. Cyp mRNA induction in livers of PXR knockout and wild type Sprague-Dawley rats
Additional Information
PXR is involved in the induction of cytochrome p4503A (CYP3A1) and is abundantly expressed in the liver and intestine. This model is useful for studying metabolism of xenobiotic compounds and hepatotoxicity.
