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Park7 (DJ-1) Knockout Rat
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Park7 (DJ-1) Knockout Rat
Nomenclature:
LEH-
Park7
tm1sage
Genotype:
Homozygous
Product number:
TGRL4830
Description
Developed in collaboration with the Michael J Fox Foundation, this model contains a deletion of the Park7 (Parkinson disease [autosomal recessive, early onset] 7) gene, also known as DJ-1.
Additional Information
In humans, loss of function of Park7 leads to a form of early-onset Parkinson's disease. This occurs due to the role Park7 plays in protecting neurons from oxidative stress and cell death, making this an ideal model for the study of Parkinson's disease.
CharacteristicsHomozygous knockout rats exhibit
complete loss of target protein as demonstrated by Western Blot
Background strain: Long Evans
complete loss of target protein as demonstrated by Western Blot
Research Applications
- Parkinson's disease
- Dopaminergic cell stress
