Park7 (DJ-1) Knockout Rat
Model Detail >
- Parkinson's disease
- Dopaminergic cell toxicity
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Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Park7 (Parkinson disease [autosomal recessive, early onset] 7) gene, also known as DJ-1. Park7 knockout rats show both motor impairments and dopaminergic cell loss, making this a useful model of Parkinson’s disease.
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Homozygous knockout rats exhibit complete loss of target protein as demonstrated by Western blot
Approximately 30% of DJ-1 knockout rats show a hindlimb-dragging phenotype that emerges at 4–6 weeks of age and worsens at 5 months
DJ-1 knockout rats show impaired open-field mobility at 8 months of age
DJ-1 knockout rats show gait impairments at 8 months of age
Preliminary reports have suggested DJ-1 knockout rats show a ~50% reduction in dopaminergic neurons in the substantia nigra at 8 months of age
Background Strain: Long Evans Hooded
Figure 1. Decreased open-field mobility in DJ-1 knockout rats
Impairments in open-field mobility were seen in 5 of 15 DJ-1 knockout rats at 8 months of age.
Figure 2. Impaired gait in DJ-1 knockout rats
DJ-1 knockout rats show impaired gait in an open field. Impairment was seen in 5 of 15 animals at 8 months of age.
In humans, loss of function of Park7 leads to a form of early-onset Parkinson's disease. This occurs due to the role Park7 plays in protecting neurons from oxidative stress and cell death, making this an ideal model for the study of Parkinson's disease.