Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Park7 (Parkinson disease [autosomal recessive, early onset] 7) gene, also known as DJ-1. Park7 knockout rats show both motor impairments and dopaminergic cell loss, making this a useful model of Parkinson’s disease.
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Figure 1. Decreased open-field mobility in DJ-1 knockout rats
Impairments in open-field mobility were seen in 5 of 15 DJ-1 knockout rats at 8 months of age.
Figure 2. Impaired gait in DJ-1 knockout rats
DJ-1 knockout rats show impaired gait in an open field. Impairment was seen in 5 of 15 animals at 8 months of age.
In humans, loss of function of Park7 leads to a form of early-onset Parkinson's disease. This occurs due to the role Park7 plays in protecting neurons from oxidative stress and cell death, making this an ideal model for the study of Parkinson's disease.
