Boost your PK/PD studies to new levels with the ADME Knockout Rat collection from SAGE™ Labs. Learn More
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Developed in collaboration with the Michael J Fox Foundation, this model contains a deletion of the Park2 gene, Parkinson disease (autosomal recessive, juvenile) 2, encoding for the protein Parkin.
In humans, loss of function of Park2 leads to a form of familial Parkinson's disease. The Parkin protein is part of the ubiquitin-proteasomal enzyme pathway and may help degrade other proteins that are toxic to neurons. Roughly 20% of patients with Parkinson's disease onset before age 40 have mutations within Park2, making this an ideal model for the study of Parkinson's disease.
complete loss of target protein as demonstrated by Western Blot
- Parkinson's disease
- Dopaminergic cell toxicity
