Oct1 Knockout Rat
Model Detail >
- Drug transport
- Drug-drug interactions
- Drug metabolism
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This model contains an 11 bp bi-allelic deletion within exon 1 of the Slc22a1 solute carrier family 22 (organic cation transporter), member 1, encoding for the basolateral hepatocyte uptake transporter OCT1.
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- Oct1 (-/-) rats have increased exposure to specific substrates
Oct1 is involved in disposition and excretion through its role in xenobiotic uptake in the basolateral membrane of the liver. Polymorphisms within the gene also have clinical relevance - making this a useful model for studying drug-drug interations, toxicity and metabolism in the liver.