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This model contains a 726 base pair bi-allelic deletion within the Mrp2 gene, synonym Abcc2 (ATP-binding cassette, sub-family C [CFTR/MRP], member 2), encoding a multispecific organic anion transporter.
Mrp2 is expressed in the liver and functions in biliary transport. The gene’s substrates include anticancer compounds such as vinblastine, enabling it to confer multiple drug resistance to tumor cells.
Sprague-Dawley background strain
Homozygous knockouts display total loss of protein via Western blot
- Homozygous pups display hyperbilirubinemia
- Total loss of Mrp2 protein via Western Blot
- Decreased elimination of the specific substrate Glutathione
- Drug transport
- Drug resistance studies
- Studying excretion pathways in cancer
- Dubin-Johnson syndrome
- Drug metabolism
Purina #5008
