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sideFadeLine
Mrp2 Knockout Rat
Model Detail >
Blue Fade Line
Nomenclature: SD- Abcc2 tm1sage
Genotype: Homozygous
Product number: TGRS4340
Research Applications
  • DMPK
  • PK/PD
  • Formulation
  • Efflux assays
  • Efficacy
  • Drug-drug interactions
  • Tissue distribution
  • Dubin-Johnson syndrome

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Description

Homozygous Mrp2 null rats display compromised biliary excretion and hyperbilirubinemia. This results in accumulation of glutathione-conjugated drugs in the liver.

Characteristics
  • Biallelic 726 bp deletion within Abcc2 gene
  • Homozygous knockouts display total loss of protein via Western blot
  • Decreased transport of endogenous glutathione
  • Hyperbilirubinemia
  • Background Strain: Sprague-Dawley

Table 1. Glutathione level of Mrp2 (-/-) and wild type rats (nM/g)

Table 2. Serum chemistry for Mrp2 (-/-) and wild type rats

Recommended Diet

Purina #5008

Additional Information

Mrp2 is expressed in the liver and functions in biliary transport. The gene’s substrates include anticancer compounds such as vinblastine, enabling it to confer multiple drug resistance to tumor cells. This model is useful for forumational, efficacy, tissue distribution, and DMPK assays.

Publications