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Mrp2 Knockout Rat
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Mrp2 Knockout Rat
Nomenclature: SD- Abcc2 tm1sage
Genotype: Homozygous
Product number: TGRS4340
Description

This model contains a 726 base pair bi-allelic deletion within the Mrp2 gene, synonym Abcc2 (ATP-binding cassette, sub-family C [CFTR/MRP], member 2), encoding a multispecific organic anion transporter.

Additional Information

Mrp2 is expressed in the liver and functions in biliary transport. The gene’s substrates include anticancer compounds such as vinblastine, enabling it to confer multiple drug resistance to tumor cells.

Characteristics

Sprague-Dawley background strain
Homozygous knockouts display total loss of protein via Western blot

  • Homozygous pups display hyperbilirubinemia
  • Total loss of Mrp2 protein via Western Blot
  • Decreased elimination of the specific substrate Glutathione
Research Applications
  • Drug transport
  • Drug resistance studies
  • Studying excretion pathways in cancer
  • Dubin-Johnson syndrome
  • Drug metabolism
Diet

Purina #5008