Lrrk2 Knockout Rat
Model Detail >
- Parkinson's disease
- Neuronal apoptosis
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Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Lrrk2 gene, encoding for the leucine-rich repeat kinase 2. Mutations in Lrrk2 are the most common monogenic cause of Parkinson’s disease. This model is useful in understanding Lrrk2 biology.
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Homozygous knockout rats exhibit complete loss of target protein as demonstrated by Western blot
Lrrk2 knockout rats display dark kidneys, similar to observations made in Lrrk2 knockout mice
Lrrk2 knockout rats are significantly larger than wild type controls
Background Strain: Long Evans Hooded
Figure 1. Kidney pathology in Lrrk2 knockout rats
Kidney from a Lrrk2 knockout rat at 37 weeks of age. The kidney is dark in color, a phenotype similar to observations in Lrrk2 knockout mice (Herzig MC, et al. Hum Mol Genet (2011) 20 (21): 4209–4223). Image courtesy of PsychoGenics.
Figure 2. Rotarod performance of Lrrk2 knockout rats at 12 months of age
Lrrk2 knockout animals show no deficits in motor activity as assessed by rotarod at 12 months of age.
Lrrk2 mutations account for 5-6% of familial Parkinson’s dieases and 1-3% in sporadic PD. Collectively, these mutations result in the most common cause of PD, making this an important model for the study of Parkinson’s disease.