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Lrrk2 Knockout Rat
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Lrrk2 Knockout Rat
Nomenclature:
LEH-
Lrrk2
tm1sage
Genotype:
Homozygous
Product number:
TGRL4620
Description
Developed in collaboration with the Michael J Fox Foundation, this model contains a deletion of the Lrrk2 gene, encoding for the leucine-rich repeat kinase 2.
Additional Information
Lrrk2 mutations account for 5-6% of familial Parkinson’s dieases and 1-3% in sporadic PD. Collectively, these mutations result in the most common cause of PD, making this an important model for the study of Parkinson’s disease.
CharacteristicsHomozygous knockout rats exhibit
complete loss of target protein as demonstrated by Western Blot
Background strain: Long Evans
complete loss of target protein as demonstrated by Western Blot
Research Applications
- Parkinson's disease
- Neuronal apoptosis
