Cox2 Knockout Rat
Cryopreserved - Please inquire for pricing and availability
Model Detail >
- Rheumatoid arthritis
- Inflammation/Autoimmune disorders
- Multiple sclerosis
- Thrombosis/Cardiac fibrosis
- Vascular defects
- Platelet defects/Platelet aggregation
- Renal dysplasia
- Crohn’s disease
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COX2 is one of the isoenzymes from Cyclooxygenase (COX) family and is responsible for inflammation and pain. Several pain relieving drugs such as Celecoxib and Rofecoxib selectively target COX2.
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- Homozygous knockouts display loss of COX2 protein via Western blot
- Background Strain: Sprague-Dawley
Figure 1. Homozygous knockout rats display loss of COX2 protein
Peritoneal macrophages were isolated from a wild type or a Cox2 homozygous knockout (COX2 -/-) rat and cultured in the presence or absence of LPS overnight. Lysates from these cultured macrophages were subjected to Western blot with the anti-COX2 antibody from Cell Signaling Technology (#4842). Rat COX2 protein is ~74 kDa.