Cyclooxygenase (COX), also known as prostaglandin synthase (PHS) and prostaglandin endoperoxide synthetase (PES), is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane.
Rats deficient in COX1 can be used for studying inflammation, thrombosis, vascular defects, platelet defects and alterations in platelet aggregation.
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Figure 1. Homozygous knockout rats exhibit complete loss of COX1 protein
Kidney and liver lysates were isolated from wild type SD (WT) and COX1 homozygous knockout rats. Rat COX1 protein is ~70 kDa. Actin (42 kDa) was used as loading control. Anti-COX1 antibody was from Upstate (06-970).
Normal rat chow
