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sideFadeLine
C57BL/6 Inbred Mouse
Model Detail >
Blue Fade Line
Nomenclature: C57BL/6NTac/Aai: BR
Genotype: Wild type
Product number: TGMCW
Research Applications
  • Genetics
  • Developmental biology
  • Immunology
  • Neurobiology
  • Cardiovascular disease
  • Diabetes
  • Obesity

Downloads

application/pdf iconC57 Mouse (14) Boyertown Health Report 3.21.13.pdf
File size: 28.62k
Description

The C57BL mouse is one of the most widely used strains in both animal research and the development of mutant mouse lines. Classified as an inbred, C57BL/6 results from a crossing of no fewer than 20 consecutive generations of brother-sister matings, which allows the offspring to possess both genetic and phenotypic uniformity.

Request a quote and a SAGE® Labs research specialist will contact you with an estimated price and delivery date.

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Characteristics
  • Coat color: black
  • Most common inbred strain to induce mutation
  • High alcohol and morphine preference
  • Low incidence of mammary tumors
  • Resistance to audiogenic seizures
  • High susceptibility to diet-induced atherosclerosis
  • High incidence of microphthalmia
  • Susceptibility to chronic ulcerative dermatitis
  • Susceptibility to noise-induced hearing loss
  • Resistance to radiation
  • Resistance to anaphylactic shock
  • Age-related hearing loss is common at 12–18 months of age
  • Average litter size of 6–8 pups and weaning occurs at 20 days of age

View larger image

Figure 1. C57BL/6 age/weight curve

Additional Data
Recommended Diet

LabDiet #5P13 (Trudeau)

Additional Information

Origin: Taconic Farms, Germantown, NY, December 1999. Barrier-maintained subline.

The female C57BL/6 are used commonly for embryo donation. They superovulate well, and they are popular for DNA microinjection.

The blastocysts from C57BL/6 are commonly used as recipients for embryonic stem cells when creating knockouts.

The females can be poor mothers, however. It is not uncommon to statistically see high newborn mortality rates and cannibalization from first time mothers.