C57BL/6 Inbred Mouse
Model Detail >
- Developmental biology
- Cardiovascular disease
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The C57BL mouse is one of the most widely used strains in both animal research and the development of mutant mouse lines. Classified as an inbred, C57BL/6 results from a crossing of no fewer than 20 consecutive generations of brother-sister matings, which allows the offspring to possess both genetic and phenotypic uniformity.
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- Coat color: black
- Most common inbred strain to induce mutation
- High alcohol and morphine preference
- Low incidence of mammary tumors
- Resistance to audiogenic seizures
- High susceptibility to diet-induced atherosclerosis
- High incidence of microphthalmia
- Susceptibility to chronic ulcerative dermatitis
- Susceptibility to noise-induced hearing loss
- Resistance to radiation
- Resistance to anaphylactic shock
- Age-related hearing loss is common at 12–18 months of age
- Average litter size of 6–8 pups and weaning occurs at 20 days of age
Figure 1. C57BL/6 age/weight curve
Origin: Taconic Farms, Germantown, NY, December 1999. Barrier-maintained subline.
The female C57BL/6 are used commonly for embryo donation. They superovulate well, and they are popular for DNA microinjection.
The blastocysts from C57BL/6 are commonly used as recipients for embryonic stem cells when creating knockouts.
The females can be poor mothers, however. It is not uncommon to statistically see high newborn mortality rates and cannibalization from first time mothers.