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Rag2 Knockout Rat
Model Detail >
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Rag2 Knockout Rat
Nomenclature: SD- Rag2 tm1sage
Genotype: Homozygous
Product number: In Development
List pricing: TBD

Request a quote and a SAGE™ Labs research specialist will contact you with an estimated price and delivery date.

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Description - This model will contain a bi-allelic deletion within the Rag2 (Recombination activating 2) gene, encoding for the Recombination activating protein 2, which is essential for the development of mature B and T lymphocytes.
Additional Information
Mature B and T cells are critical components for an adaptive immune system. Rats deficient in Rag2 protein produce no mature B or T cells. This non-leaky model for severe combined immune deficiency is useful for vaccine development, autoimmune and infectious diseases.
Research Applications

AIDS and other autoimmune disorders
Vaccine development
Transplantation studies
Hematopoieses
Immune cell differentiation

 
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