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SAGE Labs Models in Development ::
  • CACNA1C Bi-Polar disorder - Neuroscience

    CACNA1C was identified through genome association studies to be a candidate for Bi-Polar Disorder.

  • Oprd1 (DOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Ank3 Bi-Polar disorder Neuroscience

    Ank3 was identified through genome association studies to be a candidate for Bi-Polar Disorder.

  • Scn9A pain/sensorial - Neuroscience

    Sodium Channel 1.7 deficient rats could be useful for sensorial perception research.

  • Oprm1 (MOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Oprk1 (KOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Brd1 Bi-Polar disorder - Neuroscience

    Brd1 was identified through genome association studies to be a candidate for Bi-Polar Disorder.

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Animal Research Models Banner
PXR Knockout Rat
Model Detail >
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PXR Knockout Rat
Nomenclature: SD- Nr1i2 tm1sage
Genotype: Homozygous
Product number: In Development
List pricing: TBD

Request a quote and a SAGE™ Labs research specialist will contact you with an estimated price and delivery date.

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Description - This model will contain a bi-allelic deletion within the Nr1i2 (nuclear receptor, sub-family 1, group I, member 2) gene, encoding for the Pregnane X receptor (PXR).
Additional Information
PXR is involved in the induction of cytochrome p4503A (CYP3A) and is abundantly expressed in the liver and intestine. This model is useful for studying the metabolism of xenobiotic compounds and hepatotoxicity.
Research Applications

Drug transport
Cytochrome p450 pathways
Drug metabolism
Hepatotoxicity
Cholestasis

 
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