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SAGE Labs Models in Development ::
  • Oprd1 (DOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Oprm1 (MOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Oprk1 (KOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Scn9A pain/sensorial - Neuroscience

    Sodium Channel 1.7 deficient rats could be useful for sensorial perception research.

  • Ank3 Bi-Polar disorder Neuroscience

    Ank3 was identified through genome association studies to be a candidate for Bi-Polar Disorder.

  • CACNA1C Bi-Polar disorder - Neuroscience

    CACNA1C was identified through genome association studies to be a candidate for Bi-Polar Disorder.

  • Brd1 Bi-Polar disorder - Neuroscience

    Brd1 was identified through genome association studies to be a candidate for Bi-Polar Disorder.

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Why rats?

METABOLIC SIMILARITY
The rat's metabolism is far more indicative of human disease than that of mice, making it a better model for studying ADME and cardiobiology.

COGNITIVE SIMILARITY
The cognitive behavior of rats is far more advanced than that of mice, making them suitable models for studying learning, memory, addiction and neurological diseases.

PHYSIOLOGICAL SIMILARITY
Rat physiology is better suited for the study of human toxicology, pharmacokinetics and immunology.

SIZE
Rats are simply larger animals, making surgical procedures and multiple blood extractions much more simple and successful.

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