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SAGE Labs Models in Development ::
  • Oprd1 (DOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Oprm1 (MOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Brd1 Bi-Polar disorder - Neuroscience

    Brd1 was identified through genome association studies to be a candidate for Bi-Polar Disorder.

  • CACNA1C Bi-Polar disorder - Neuroscience

    CACNA1C was identified through genome association studies to be a candidate for Bi-Polar Disorder.

  • Scn9A pain/sensorial - Neuroscience

    Sodium Channel 1.7 deficient rats could be useful for sensorial perception research.

  • Oprk1 (KOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Ank3 Bi-Polar disorder Neuroscience

    Ank3 was identified through genome association studies to be a candidate for Bi-Polar Disorder.

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Animal Research Models Banner
Snca Knockout Rat
Model Detail >
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Snca Knockout Rat
Nomenclature: SD- Snca tm1sage
Genotype: Homozygous
Product number: In Development
List pricing: TBD

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Description - This model will contain a bi-allelic deletion within the Snca gene, encoding for synuclein, alpha (non-A4 component of amyloid precursor) protein, which plays a role in synaptic biogenesis and organization.
Additional Information
Alpha-synuclein has been implicated in several neurodegenerative diseases, including Parkinson's and dementia. It is thought to regulate dopamine synthesis. Mutations within the gene are also present in some Alzheimer's disease cases, making this model important for the study neurodegeneration.
Research Applications

Parkinson's disease
Alzheimer's disease
Dementia
Multiple system atrophy
Alcohol consumption

 
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