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SAGE Labs Models in Development ::
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  • Oprd1 (DOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Oprk1 (KOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • CACNA1C Bi-Polar disorder - Neuroscience

    CACNA1C was identified through genome association studies to be a candidate for Bi-Polar Disorder.

  • Ank3 Bi-Polar disorder Neuroscience

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  • Scn9A pain/sensorial - Neuroscience

    Sodium Channel 1.7 deficient rats could be useful for sensorial perception research.

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Animal Research Models Banner
Rag2 Knockout Rat
Model Detail >
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Rag2 Knockout Rat
Nomenclature: SD- Rag2 tm1sage
Genotype: Homozygous
Product number: In Development
List pricing: TBD

Request a quote and a SAGE™ Labs research specialist will contact you with an estimated price and delivery date.

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Description - This model will contain a bi-allelic deletion within the Rag2 (Recombination activating 2) gene, encoding for the Recombination activating protein 2, which is essential for the development of mature B and T lymphocytes.
Additional Information
Mature B and T cells are critical components for an adaptive immune system. Rats deficient in Rag2 protein produce no mature B or T cells. This non-leaky model for severe combined immune deficiency is useful for vaccine development, autoimmune and infectious diseases.
Research Applications

AIDS and other autoimmune disorders
Vaccine development
Transplantation studies
Hematopoieses
Immune cell differentiation

 
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