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SAGE Labs Models in Development ::
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  • Ank3 Bi-Polar disorder Neuroscience

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  • Oprm1 (MOR1) - pain/drug addiction - Neuroscience

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  • Brd1 Bi-Polar disorder - Neuroscience

    Brd1 was identified through genome association studies to be a candidate for Bi-Polar Disorder.

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Animal Research Models Banner
Rag1 Knockout Rat
Model Detail >
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Rag1 Knockout Rat
Nomenclature: SD- Rag1 tm1sage
Genotype: Homozygous
Product number: In Development
List pricing: TBD

Request a quote and a SAGE™ Labs research specialist will contact you with an estimated price and delivery date.

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Description - This model will contain a bi-allelic deletion within the Rag1 (Recombination activating 1) gene, encoding for the Recombination activating protein 1, which is essential for the development of mature B and T lymphocytes.
Additional Information
Mature B and T cells are critical components for an adaptive immune system. Rats deficient in Rag1 protein produce no mature B or T cells. This non-leaky model for severe combined immune deficiency is useful for vaccine development, as well as the study of autoimmune and infectious diseases.
Research Applications

AIDS and other autoimmune disorders
Vaccine development
Transplantation studies
Hematopoieses
Immune cell differentiation

 
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