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Boost your PK/PD studies to new levels with the ADME Knockout Rat collection from SAGE™ Labs. Learn More
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PXR Knockout Rat
Model Detail >
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PXR Knockout Rat
Nomenclature:
SD-
Nr1i2
tm1sage
Genotype:
Homozygous
Product number:
In Development
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Description
This model will contain a bi-allelic deletion within the Nr1i2 (nuclear receptor, sub-family 1, group I, member 2) gene, encoding for the Pregnane X receptor (PXR).
Additional Information
PXR is involved in the induction of cytochrome p4503A (CYP3A) and is abundantly expressed in the liver and intestine. This model is useful for studying the metabolism of xenobiotic compounds and hepatotoxicity.
Research Applications
- Drug transport
- Cytochrome p450 pathways
- Drug metabolism
- Hepatotoxicity
- Cholestasis
