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Prkdc Knockout Rat
Model Detail >
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Prkdc Knockout Rat
Nomenclature:
SD-
Prkdc
tm1sage
Genotype:
Homozygous
Product number:
In Development
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Description
This model will contain a bi-allelic deletion within the Prkdc (protein kinase, DNA-activated, catalytic polypeptide) gene, which is a component of the autoimmune antigen Ku.
Additional Information
Loss of Prkdc function results in severe combined immunodeficiency due to lack of V(D)J recombination.
Research Applications
- Autoimmune disorders
- Xenograft studies
