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SAGE Labs Models in Development ::
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Park2 Knockout Rat
Model Detail >
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Park2 Knockout Rat
Nomenclature: SD- Park2 tm1sage
Genotype: Homozygous
Product number: In Development
List pricing: TBD

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Description - This model will contain a bi-allelic deletion within the Park2 gene, Parkinson disease (autosomal recessive, juvenile) 2, encoding for the protein Parkin that localizes to the cytoplasm of neurons and mediates the degradation of improperly folded proteins.
Additional Information
In humans, loss of function of Park2 leads to a form of familial Parkinson's disease. The Parkin protein is part of the ubiquitin-proteasomal enzyme pathway and may help degrade other proteins that are toxic to neurons. Roughly 20% of patients with Parkinson's disease onset before age 40 have mutations within Park2, making this an ideal model for the study of Parkinson's disease.
Research Applications

Parkinson's disease
Dopaminergic cell toxicity

 
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