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Tp53 Knockout Rat
Model Detail >
Tp53 Knockout Rat
Nomenclature:
SD-
Tp53
tm1sage
Genotype:
Homozygous
Product number:
TGRS3990
List pricing:
$445 USD
Description -
This model contains a bi-allelic 14 base pair deletion within exon 3 of the most commonly mutated gene in human cancers, Tp53 (Tumor protein p53). This deletion causes a frameshift in the coding region, resulting in a premature termination codon at the end of exon 3.
Additional Information
p53 is a tumor suppressor protein encoded by the Tp53 gene. Its role in cell cycle regulation and stabilization for preventing genome mutation is observable among a wide variety of multicellular organisms, including humans, rodents, frogs and fish. Homozygous rats deficient in p53 protein are prone to spontaneous tumors, making them valuable for in vivo screening of carcinogenicity, as well as studying chemopreventive and therapeutic treatment.
p53 is a tumor suppressor protein encoded by the Tp53 gene. Its role in cell cycle regulation and stabilization for preventing genome mutation is observable among a wide variety of multicellular organisms, including humans, rodents, frogs and fish. Homozygous rats deficient in p53 protein are prone to spontaneous tumors, making them valuable for in vivo screening of carcinogenicity, as well as studying chemopreventive and therapeutic treatment.
Characteristics
Total loss of protein via Western blot
Early onset of tumors
High degree of malignancy
Research Applications
Early carcinogenicity screening
Chemopreventive/Chemotherapeutic screening
p53 function studies
Diet
Purina #5008
