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SAGE Labs Models in Development ::
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    CACNA1C was identified through genome association studies to be a candidate for Bi-Polar Disorder.

  • Ank3 Bi-Polar disorder Neuroscience

    Ank3 was identified through genome association studies to be a candidate for Bi-Polar Disorder.

  • Oprm1 (MOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Oprd1 (DOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Scn9A pain/sensorial - Neuroscience

    Sodium Channel 1.7 deficient rats could be useful for sensorial perception research.

  • Oprk1 (KOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Brd1 Bi-Polar disorder - Neuroscience

    Brd1 was identified through genome association studies to be a candidate for Bi-Polar Disorder.

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Animal Research Models Banner
Mrp1 Knockout Rat
Model Detail >
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Mrp1 Knockout Rat
Nomenclature: SD- Abcc1a tm1sage
Genotype: Homozygous
Product number: In Development
List pricing: TBD

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Description - This model will contain a bi-allelic deletion within the Mrp1 gene, synonym Abcc1a (ATP-binding cassette, sub-family C [CFTR/MRP], member 1a), encoding an ATP-dependent drug transporter.
Additional Information
Mrp1 is a multispecific organic anion transporter that extrudes glutathione-, glucouronide- or sulfate-conjugated substrates (steroids, leukotrienes, etc.), as well as xenobiotic drugs out of cells. Mrp1 can confer multiple drug resistance to tumor cells. Absence of Mrp1 creates a functional deficiency in the cellular transport of some substrates and results in compromised inflammatory response, making this model useful for studying drug transport in inflammatory stimulus response and chemotherapeutic agents.
Research Applications

Drug transport
Drug resistance studies
Studying excretion pathways in cancer

 
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