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SAGE Labs Models in Development ::
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Animal Research Models Banner
Leptin Knockout Rat
Model Detail >
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Leptin Knockout Rat
Nomenclature: SD- Lept m1sage
Genotype: Homozygous
Product number: In Development
List pricing: TBD

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Description - This model will contain a bi-allelic deletion within the obesity gene, Lep, encoding for the protein leptin. Leptin plays a key role in regulating appetite and metabolism.
Additional Information
Leptin is essential for normal energy intake and expenditure. It is one of the most important adipose-derived hormones, being primarily expressed in adipocytes of white adipose tissue. Loss of function of leptin creates an uncontrolled appetite leading to severe obesity, making this a useful model for the study of lifestyle diseases, such as diabetes, atherosclerosis, high cholesterol, and high blood pressure.
Research Applications

Cholesterol/Triglyceride metabolism
Lipoprotein transport
Atherosclerosis
Obesity
Adipose hormone signaling
Hypertension

 
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