Boost your PK/PD studies to new levels with the ADME Knockout Rat collection from SAGE™ Labs. Learn More
Expand your research — New inbred
and outbred mouse and rat strains from
SAGE™ Labs. Learn More
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This model will contain a bi-allelic deletion within the Ldlr (low-density lipoprotein receptor) gene, encoding for the protein Ldlr.
Ldlr mediates the endocytosis of cholesterol-rich low-density lipoproteins (LDL) and is important for the proper regulation of LDL circulation within the blood. Expressed in the liver, loss of function of Ldlr leads to accumulation of excess LDL, which directly contributes to atherosclerosis, making this a useful model for the study of cardiovascular disease.
Homozygous Ldlr knockouts are a little heavier than wild-type Sprague-Dawley rats
Homozygous Ldlr knockouts demonstrate significantly higher Cholesterol levels at both 5 and 10 weeks of age
See the 8-page Cardiovascular Knockout Rat Collection brochure for details
- Cholesterol/Triglyceride metabolism
- Lipoprotein transport
- Atherosclerosis
- Cardiovascular disease
- Hypertension
Normal rat chow
