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Ldlr Knockout Rat
Model Detail >
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Ldlr Knockout Rat
Nomenclature: SD- Ldlr tm1sage
Genotype: Homozygous
Product number: In Development
List pricing: TBD

Request a quote and a SAGE™ Labs research specialist will contact you with an estimated price and delivery date.

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Description - This model will contain a bi-allelic deletion within the Ldlr (low-density lipoprotein receptor) gene, encoding for the protein Ldlr.
Additional Information
Ldlr mediates the endocytosis of cholesterol-rich low-density lipoproteins (LDL) and is important for the proper regulation of LDL circulation within the blood. Expressed in the liver, loss of function of Ldlr leads to accumulation of excess LDL, which directly contributes to atherosclerosis, making this a useful model for the study of cardiovascular disease.
Research Applications

Cholesterol/Triglyceride metabolism
Lipoprotein transport
Atherosclerosis
Cardiovascular disease
Hypertension

 
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