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SAGE Labs Models in Development ::
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    Brd1 was identified through genome association studies to be a candidate for Bi-Polar Disorder.

  • Oprk1 (KOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • CACNA1C Bi-Polar disorder - Neuroscience

    CACNA1C was identified through genome association studies to be a candidate for Bi-Polar Disorder.

  • Ank3 Bi-Polar disorder Neuroscience

    Ank3 was identified through genome association studies to be a candidate for Bi-Polar Disorder.

  • Oprm1 (MOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Scn9A pain/sensorial - Neuroscience

    Sodium Channel 1.7 deficient rats could be useful for sensorial perception research.

  • Oprd1 (DOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

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Animal Research Models Banner
Bcrp Knockout Rat
Model Detail >
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Bcrp Knockout Rat
Nomenclature: SD- Abcg2 tm1sage
Genotype: Homozygous
Product number: In Development
List pricing: TBD

Request a quote and a SAGE™ Labs research specialist will contact you with an estimated price and delivery date.

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Description - This model will contain a bi-allelic deletion within the Bcrp gene, synonym Abcg2 (ATP-binding cassette, subfamily G, member 2), encoding for an ATP drug transporter.
Additional Information
Loss of function of Bcrp leads to improper transport of drugs across epithelial cells. This model is useful for studying metabolism of xenobiotic compounds and multiple drug-resistant tumors.
Research Applications

Drug transport
Drug resistance studies
Drug metabolism

 
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