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This model contains a 588 base pair bi-allelic deletion within the Bcrp gene, synonym Abcg2 (ATP-binding cassette, subfamily G, member 2), encoding for an ATP drug transporter.
Loss of function of Bcrp leads to improper transport of drugs across epithelial cells and increased bioavailability of Bcrp substrates. This model is useful for studying metabolism of xenobiotic compounds and multiple drug-resistant tumors.
Sprague-Dawley background strain
Homozygous knockouts display total loss of protein via Western blot
- Decreased elimination of the substrate drug Dantrolene in the Brain
- Increased bioavailability of the substrate drug Sulfasalazine
- Drug transport
- Drug resistance studies
- Drug metabolism
- Chemotherapeutic resistance
Purina #5008
