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SAGE Labs Models in Development ::
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    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

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ApoE Knockout Rat
Model Detail >
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ApoE Knockout Rat
Nomenclature: SD- ApoE tm1sage
Genotype: Homozygous
Product number: In Development
List pricing: TBD

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Description - This model will contain a bi-allelic deletion within the ApoE gene, encoding a glycoprotein, Apolipoprotein E.
Additional Information
ApoE is essential for the normal metabolism of lipids. It is expressed in the liver, intestines and brain, preventing the accumulation of cholesterol-rich particles in plasma. Widely studied for its role in cardiovascular disease and lipoprotein transport, it has more recently been implicated in Alzheimer’s disease and cognition, making this a useful model for the study of atherosclerosis, Alzheimer’s and nerve injury.
Research Applications

Cholesterol/triglyceride metabolism
Lipoprotein transport
Atherosclerotic plaque formation
Alzheimer’s disease
Nerve regeneration

 
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