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SAGE Labs Models in Development ::
  • Scn9A pain/sensorial - Neuroscience

    Sodium Channel 1.7 deficient rats could be useful for sensorial perception research.

  • Oprk1 (KOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Oprd1 (DOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Ank3 Bi-Polar disorder Neuroscience

    Ank3 was identified through genome association studies to be a candidate for Bi-Polar Disorder.

  • CACNA1C Bi-Polar disorder - Neuroscience

    CACNA1C was identified through genome association studies to be a candidate for Bi-Polar Disorder.

  • Oprm1 (MOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Brd1 Bi-Polar disorder - Neuroscience

    Brd1 was identified through genome association studies to be a candidate for Bi-Polar Disorder.

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Do you have a rat model for AZ? Has it been tested with PIB and other PET imaging agents to see if plaques and tangles are targeted with the same biomarkers that work in humans?

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ApoE knockout
Submitted by ResearchModels on Mon, 02/22/2010 - 14:35.

We are developing a homozygous ApoE knockout rat. Apoe is essential for the normal metabolism of lipids. It is expressed in the liver, intestines, and brain preventing the accumulation of cholesterol rich particles in plasma. While it is widely studied for its role in cardiovascular disease and lipoprotein transport, it has more recently been implicated in Alzheimer’s disease and cognition. We feel this will be an important model for studying Alzheimer's. We are still early in development and have not looked at imaging for plaques and tangles.

Additional Alzheimer's models
Submitted by ResearchModels on Thu, 04/01/2010 - 15:35.

I should add - we are always open to ideas on new models or other disease areas the models could impact.

Do you have a rat models for AZ
Submitted by marrydavidson101 on Sun, 07/04/2010 - 23:57.

Do you have a rat model for AZ? Has it been tested with PIB and other PET imaging agents to see if plaques and tangles are targeted with the same biomarkers that work in humans?

AZ models
Submitted by ResearchModels on Thu, 08/26/2010 - 11:38.

We are working on the ApoE knockout as well as others such as APP. We do not have phenotyping on the ApoE yet. We anticipate by early 2011 it will be characterized.



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