ST. LOUIS, Dec. 7, 2011 /PRNewswire/ -- Sigma-Aldrich® Corporation (Nasdaq: SIAL) today announced that Sigma Advanced Genetic Engineering (SAGE™) Labs, an initiative of Sigma Life Science, has made available three genetically modified rat models that exhibit features...
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From SAGE™ Labs - Archive
December 2011
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Dec 7 2011
November 2011
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ST. LOUIS, Nov. 9, 2011 /PRNewswire/ -- Sigma-Aldrich® Corporation (Nasdaq: SIAL) today announced that Sigma Advanced Genetic Engineering (SAGETM) Labs, an initiative of Sigma Life Science, in partnership with Autism Speaks, will present data on the biological and behavioral characterization of...
Nov 9 2011
November 2010
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Nov 4 2010
October 2010
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Sigma Life Science announces a partnership between its SAGE Labs division and Autism Speaks to create genetically engineered knockout rats to aid identification of new therapeutic approaches for the treatment of autism. Combining the extensive knowledge of Autism Speaks with SAGE...Oct 27 2010
September 2010
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Until recently, transgenic and knockout models for disease have been limited almost exclusively to mice. Although useful, these models do not always accurately reflect the physiology and pathology of human disease. Now, advances in genetic engineering technology have extended the spectrum of...
Sep 15 2010
August 2010
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[Science Vol 329, August 20, 2010]
Fans of the rat as a lab animal have watched in frustration as a parade of mice with specific genes deleted became available to researchers over the past 2 decades. While knockout mice have become models for many human diseases and developmental biology,...Aug 20 2010
July 2010
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ABSTRACT
Homologous recombination-based gene targeting using Mus musculus embryonic stem cells has greatly impacted biomedical research. This study presents a powerful new technology for more efficient and less time consuming gene targeting in mice using embryonic injection of zinc-finger...Jul 13 2010 -
Aron M. GEURTS∗†‡ and Carol MORENO†‡
∗Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI 53226, U.S.A., †PhysGen Knockout Team,Human and Molecular Genetics Center, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, U.S.A.,and ‡Department...Jul 6 2010
June 2010
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Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases
Melanie Meyera,Martin Hrabé de Angelisb,Wolfgang Wursta,and Ralf Kühn
June 30, 2010 (received for review June 16, 2010)
Abstract
Gene targeting by homologous recombination in...Jun 30 2010
April 2010
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St. Louis, MO. – April 19, 2010 – Sigma® Life Science, the innovative biological products and services brand of Sigma-Aldrich® (NASDAQ: SIAL), today introduced the world’s first p53 ‘knockout’ rat model, an important development that is expected to, due to the rat’s closer physiological and...
Apr 19 2010
