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Community > Parkinson039s TOPIC > Park2 knockout

Do you think the Park2 knockout will be the answer to acurately modeling Parkinson's in rats?

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alpha synuclein
Submitted by perez on Fri, 10/30/2009 - 13:03.

A Park2 knockout rat would be a great start for modeling Parkinson's disease (PD). Park 2 has been identified as the cause of juvenile Parkinson's disease (PD) and some adult-onset PD. In addition to Park 2, alpha synuclein is another gene of iterest. Even though the exact function of alpha synuclein is not well understood, it is known that it plays a role in the formation of Lewy bodies in PD. Lewy body formation of alpha synuclein isoluble aggregates is the classic pathology of PD. This may point to problems in protein recycling and waste disposal in neurons. Most importantly, alpha synuclein has been identified as the cause of a rare early on-set PD due to autosomal dominant mutations (e.g. A30P and A53T). Overall, I think an alpha synuclein model would be fantastic for PD!

novel E3 ligase
Submitted by sekyuchoi on Thu, 11/19/2009 - 02:11.

Park2 is parkin, novel E3 ligase. there is possiblity that parkin has many unknown substrate to degradation. To explore the role of Park2 is fantastic to think about Parkinson's I think.

E3 Ligase
Submitted by rat_ninja on Mon, 11/23/2009 - 18:19.

It is interesting the number of things which go wrong when the proteolytic pathways of a cell are disrupted.