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SAGE Labs Models in Development ::
  • Oprd1 (DOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Oprm1 (MOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Oprk1 (KOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Scn9A pain/sensorial - Neuroscience

    Sodium Channel 1.7 deficient rats could be useful for sensorial perception research.

  • Ank3 Bi-Polar disorder Neuroscience

    Ank3 was identified through genome association studies to be a candidate for Bi-Polar Disorder.

  • CACNA1C Bi-Polar disorder - Neuroscience

    CACNA1C was identified through genome association studies to be a candidate for Bi-Polar Disorder.

  • Brd1 Bi-Polar disorder - Neuroscience

    Brd1 was identified through genome association studies to be a candidate for Bi-Polar Disorder.

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Community > Diabetes TOPIC > Lep/Alz

I see sigma is creating a Leptin knockout and some Alzheimer's models? There is some overlap in pathology that may be interesting.

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I think that it's great
Submitted by Perfectgrl02 on Thu, 10/29/2009 - 15:28.

I think that it's great we're finally moving to the next level in animal research! I foresee Leptin/AD/p53 knockout models to greatly benefit work surrounding the relationships between diabetes, aging, cognition, and cancer progression. TONS of factors you can look at in terms of potential treatment and prevention. I'd be very interested if there would be a double ko rat (i.e. ApoE-/-p53-/-)....