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SAGE Labs Models in Development ::
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    CACNA1C was identified through genome association studies to be a candidate for Bi-Polar Disorder.

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  • Scn9A pain/sensorial - Neuroscience

    Sodium Channel 1.7 deficient rats could be useful for sensorial perception research.

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    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Ank3 Bi-Polar disorder Neuroscience

    Ank3 was identified through genome association studies to be a candidate for Bi-Polar Disorder.

  • Oprm1 (MOR1) - pain/drug addiction - Neuroscience

    Opioid receptor deficient rats could be an advantage to nociception research due to their higher cognitive abilities over mice.

  • Brd1 Bi-Polar disorder - Neuroscience

    Brd1 was identified through genome association studies to be a candidate for Bi-Polar Disorder.

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Community > Diabetes TOPIC > lep knockout in rats

So the mouse leptin knockout exists and is useful for looking at diabetes. How would you anticipate the rat phenotype to be different?

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atheroscloresis
Submitted by rat_ninja on Fri, 01/29/2010 - 16:26.

It would be great if Leptin KO rats develop atherosclerosis. I would guess that they may also acquire type 2 diabetes. In either case I would prefer to have a larger model for the volume of fluid and tissue. Atherosclerotic rats will be a closer approximation to humans and the damage that excess glucose inflicts on organs will be more apparent in rats than in mice.

I found very interesting
Submitted by brown on Wed, 06/23/2010 - 00:19.

I found very interesting information in it and it is really helpful i think people should look forward to it this is really nice work done and i will refer other people to check it out...nice work done.

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