SAGE Labs specializes in the development and characterization of unique, next-generation animal research models featuring specific gene deletions, insertions, repressions and modifications using proprietary zinc-finger nuclease technology. This genetic manipulation technology works for a variety of animal research models, as well as a wide range of research applications.
Zinc-Finger Nuclease (ZFN) Technology enables rapid creation of targeted gene knockouts, genomic insertions or gene editing in eukaryotic systems. ZFNs (mRNA or plasmid formats) are delivered to cells by transfection methods or to embryos by microinjection to target your gene or genomic sequence of interest. Upon cleavage of the target site, endogenous cellular processes are harnessed to produce targeted mutations that result in gene knockout.